|
KMID : 0043319890120020138
|
|
Archives of Pharmacal Research
1989 Volume.12 No. 2 p.138 ~ p.142
|
|
|
Synthesis and Structure of Purine Derivatives as Antitumor Effects
|
|
Moharram HH
El Bayouki EAM/Haggag B/Basyouni WM/Osman AM
|
|
|
Abstract
|
|
|
|
The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|